汕头大学医学院药理学精品课程 gene polymorphism and drug and disease[1].pptVIP

Genetic polymorphism:(i) individual handling of drugs (ii) inherited susceptibility to disease Much individuality in drug response is inherited (polymorphism) PHARMACOGENETICS Menu Metabolism of drugs- phase 1 and 2 reactions what is polymorphism? Examples of polymorphic genes relevant in drug metabolism polymorphism and disease susceptibility Polymorphism polymorphism= the inheritance of genes in different forms termed alleles alleles have different DNA sequences polymorphic locus: the frequency of the most common allele is less than 99%. 1 allele in 100 alleles 100 alleles =50