汕头大学医学院药理学精品课程 Pancreatic Hormone Anti diabetic Drugs.pptVIP

Pancreatic Hormone Antidiabetic Drugs GAO Fen-Fei Background Diabetes mellitus classification: insulin-dependent diabetes mellitus (IDDM): pancreatic B cell destruction (immune-mediated in most cases) non-insulin-dependent diabetes mellitus (NIDDM): ＞90%, defects of insulin secretion and action, insulin resistance. Insulin Small protein containing 51 amino acids arranged in two chains (A and B) linked by disulfide bridges. Released from pancrearic B cells at a low basal rate and at a much higher stimulated rate in response to a variety of stimuli, especially glucose. Pharmacokinetics