补阳还五汤治疗职业性慢性锰中毒的临床研究.docVIP

补阳还五汤治疗职业性慢性猛中毒的临床研究 李 娜闫珞的孙瑞玲王慧(山东中医药大学第二附属医院职业病科 山东济 南 250001) 【中图分类号】R135.1【文献标识码】A【文章编号】1672?5085 (2011)01-0099-03 【摘要】 目的 观察补阳还五汤治疗职业性慢性猛中毒的临床疗效。方法 收集53例职业性慢性镭中毒患者临床资料，随机分为治疗组(25例)和对照组 (28例)，治疗组给予补阳还五汤口服，对照组给予口服盐酸氟桂利嗪胶囊和甲 钻胺片治疗。治疗三个月后观察两组患者临床症状体征积分及肌电图的改善情况, 并进行治疗前后及两组间比较。结果临床数据统计处理发现，治疗组患者的临 床症状、体征和肌电图均得到不同程度的改善。结论 补阳还五汤可以改善职业 性慢性猛中毒的临床症状，提高神经传导速度。肯定了补阳还五汤对职业性慢性 镭中毒的独特疗效，值得进一步开发其临床应用价值。 【关键词】 慢性猛中毒 补阳还五汤 临床研究 Clinical study on treatment of occupational chronic manganese poisoning using buyang huanwu decoction Li Na ; Yan Rong-di; Sun Rui-ling ; Wang Hui Occupational Disease Department, The Second Hospital Affiliated to Shandong University of TCM [Abstract] Objective: To observe the clinical effects of buyang huanwu decoction on occupational chronic manganism. Method: Collect information of 53 cases of occupational chronic manganese were randomly divided into the treatment group (25 patients) and control group (28 patients). The patients in treatment group were given buyang huanwu decoction. The patients in control group were given mecobalamin tablets and flunarizine hydrochloride capsules? The changes of every subject for his clinical symptoms, signs and amplitude were observed in both groups. Result: After 3 mon ths, the clin ical symptoms, signs and amplitude of the occupational chronic manganese patients of the treatment group, all get different degree of improvement. Conclusion: The traditional Chinese medicine of buyang huanwu decoction can relieve clinical symptoms of occupational chronic manganese patients, improve nerve conduction relocity. Affirmed buyang huanwu decoction of patients with occupational chronic manganism unique efficaey, worthy of further explore their clinical value. 【Key words] Occupational chronic manganism Buyang huanwu decoction Clinical study 职业性慢性镒中毒是一种因金属镒及其化合物所导致的职业中毒，为探索更 好的治疗方法，我们采用补阳还五汤对25例患者进行了辩证治疗，并与单用西 药治疗的一组患者进行了对照分析，现将结果报告如下。 1资料及方法 1.1 一般资料 选择2008年1月至2009年月本院住院及门诊患者70例。 参照《职业性慢性镒中毒诊断标准GBZ 3-2006》⑴诊断及分级标准、《中药新药 临床研究指导原则