汕头大学医学院药理学精品课程 antiatherosclerotic drugs.pptVIP

Antiatherosclerosis drugs Lipid-regulating drugs Background Lipoprotein Classification of Lipoprotein: CM、VLDL、IDL、LDL、HDL、Lp(a) Hyperlipoprotein: VLDL、IDL、LDL、apoB HDL 、apoA Hyperlipoprotein Antiatherosclerosis : VLDL、 LDL 、TC、TG 、 apoB HDL 、apoA HMG-CoA reductase inhibitors(---statins) Drugs: mevastatin, lovastatin and their derivatives Pharmacological effects: Apparently decrease plasma TC and LDL-Cholesterol Mechanism: HMG-CoA mevalonic acid(MVA) hepatic Ch synthesis LDL-R Clinic use: fi