汕头大学医学院药理学精品课程 Antihypertensive agents.pptVIP

Antihypertensive drugs BACKGROUND NBP 120-90/90-60mmHg, Affecting factors: Volume of blood, Cardiac Output, resistance of Arterioles HBP SBP140/ DBP90 mmHg Morbidity 30% CLASSES OF HYPERTENISON Essential hypertension Secondary hypertension CLASSES OF DRUGS DRUGS Targets Diuretics Agents act on ANS. Direct Vasodilators CCB RAS blockers (ACEI, AT1B) Diuretics Agents Furosemide (Lasix) thiazides Mechanism Blood Volume Na Na Ca Ca Na PGE2, Kinin reactivity to vaso-excitor material(NA) Diuretics Clinic uses Alone: Mild h