汕头大学医学院药理学精品课程 Antiarrhythmic agents.pptVIP

Antiarrhythmic Agents BACKGROUND Inside cell: K+ ; Outside cell: Na +, Ca + +, Cl - Action potential (AP) and Phase 0-4 phase0---reactivity---conduction--- Na + phase1--------------------------------- K + phase2,3---early afterdepolarization--- Ca + +; K + phase4---automaticity--- Na + ---delayed afterdepolarization-- Ca + +--Na + Effective Refractory Period: membrane potential~-60 mV BACKGROUND Classification of ARR according to The mechanism of ARR (disturbances of Impulse formation or conduction) The Site of the origin (SupraVentricular, V.) HR increased o