汕头大学医学院药理学精品课程 Drugs Affecting Gastrointestinal Function.pptVIP

Drugs Affecting Gastrointestinal Function OUTLINE Peptic Ulcer Digestion Vomiting Diarrhea Bile Review-Questions Ulcer-Background Epidemiology incidence of a disease: 10%-12% DU GU (3:1) Etiology General consideration: No Acid No Ulcer Main Destroy Factors: ①HCl, ②Pepsin, ③Hp Protective Barrier: Mucus-HCO3- Physiology HCl: P-cell, H2, M1, G-R, H+-pump Anti-ulcer Targets HCl Mucus Hp Anti-ulcer Classification Antacids--- Neutralize HCl Gastric Antisecretory Drugs HCl secretion Antagonize Rs. on Parietal Cell--- H2,M3, G Inhibitor of H+-Pump Protectors o