汕头大学医学院药理学精品课程 Hepatic Injury Induced By Drugs.pptVIP

Hepatic Injury Induced By Drugs GAO Fen-Fei Overview Liver’s pivotal role in the processing of foreign substances also makes it susceptible to injury by those xenobiotics. Drugs in common use can cause liver toxicity that can mimic almost every naturally occurring liver disease in humans. Classification Metabolic Acute parenchyma Chronic parenchyma Fatty liver induced by drugs Bile duct injury Hepatic blood vessel injury Hepatic tumor Metabolic Hepatic Injury Drugs interfere with Liver’s uptaking and evacuating bilirubin. Chlorpromazine, Methyldopa, Barbiturates, Tricyclic antidepressants, M