汕头大学医学院药理学精品课程 Histamine.pptVIP

Histamine and Histamine Antagonists GAO Fen-Fei Histamine Histamine is one of the most important autacoids(自泌物), and is formed from the amino acid histidine(组氨酸) and is stored in high concentrations in mast cells, and basophils(嗜碱细胞). Non-mast cell histamine is found in several tissues, including the brain, where it functions as a neurotransmitter. It may play a role in many brain functions such as neuroendocrine control, cardiovascular regulation, thermoregulation, and arousal. A second important nonneuronal site of histamine storage and release is the enterochromaffin(肠嗜铬)-like (ECL) cell o