汕头大学医学院药理学精品课程 Loccal anesthetics.pptVIP

Local Anesthetics Department of Pharmacology Zhang Yan-mei Introduction Local anesthetics: Local anesthetics act by blocking both sensory and motor nerve conduction to produce a temporary loss of sensation without a loss of consciousness. Unlike general anesthetics, they normally do not cause central nervous system (CNS) depression. General anesthetics act on the CNS or autonomic nervous system to produce analgesia, amnesia, or hypnosis. Mechanism of action Local anesthetics slow the propagation of nerve impulses by reducing the rate of rise of action potential and the rate of repolarizati