天津医科大学内科学课件 General A spects of Anemia.pptVIP

General Aspects of Anemia Hematology Department, tianjin medical university general hospital Shao Zonghong Background knowledge Blood system (1) The composition of blood system (2) The differentiation of blood cells The types of blood diseases The classification of blood diseases 1. Erythrocytic diseases 2. Leukocytic diseases 3. Hemorrhagic diseases 4. Thrombotic diseases Anemia is a kind of ‘syndrome’ rather than ‘disease’ Anemia Definition Classifications Manifestations Diagnosis Therapy Definition  The term anemia, as it generally is used in clinical medicine, refers to a reduction below normal in the concentration of hemoglobin or red cells in the blood. Normal range of RBC, Hb, Ht WHO Criteria for anemia Hemoglobin concentration adult men : 130g/L adult women: 120g/L 6 months old to 6 years old children: 110g/L 6 to 14 years old children : 120 g/L pregnant women: 110g/L Classification According to the morphologic characteristic of red cells, mainly according to MCV and MCHC . Macrocytic Anemia MCV100um3 Folic acid deficiency anemia VitaminB12 deficiency anemia Microcytic hypochromic anemia MCV80um3 MCHC 32%, Iron-deficiency anemia Sideroblastic anemia thalassemia Normocytic anemia MCV=80~100um3 Aplastic anemia the majority of hemolytic anemia anemia with chronic disorders chronic inflammation infection hepatic diseases connective diseases malignant tumors Manifestations The clinical manifestations of anemia depend on 5 factors: The reduction in the oxygen-carrying capacity of blood. The degree of change in total blood volume. The rate of which the previous two factors developed. The capacity of the cardiovascular a