基于gaba受体的药物设计资料.pptVIP

基于GABA受体的药物设计 GABA(g-aminobutyric acid)   欢迎合作，共同发展。 * * 巨修练 武汉工程大学 Model of GABA Receptor Cl- Model of Cl- Channel Polychlorated Cyclanes Picrodendrin Homologues Phenylpyrazoles Trioxabicyclooctanes Butyl benzoates Modification of GABA Antagonists [3H]EBOB Inhibition of [3H]EBOB Binding LC50rat = 1.41 mM, LC50fly = 2.90 mM Bicyclic GABA Antagonists Nematocidal Activity LD50 = 24.7 mM LC50 rat / LC50 housefly = 2360 nM / 45 nM = 52 (in vitro） Compound 15 LD50housefly = 0.04 mg/fly（in vivo） Presumption of Binding Sites Presumption of Binding Sites EBOB Possible Interaction of