三氧化二砷诱导白血病细胞凋亡的差异蛋白质组学研究-儿科学 (小儿血液)专业论文.docxVIP

Abstract: bjective: To observe the effect of apoptosis induction about various concentrations of As2O3 on AML HL-60 cell line and the differential protein expression before and after the intervention on AML HL-60 cell.To explore mechanism of As2O3 for inducting HL-60 cell apoptosis by searching some of the differences between the function of the protein,and provide the experimental basis for As2O3 curing AML.Method:1.Using HL-60 cell line as leukemia model.2.Grouping and intervention:The experiments were divided into six groups,including the experimental groups to join with 0.1,1,2,4,8umo