A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction 混合组分超分子水凝胶改善急性心肌梗死后小鼠心脏功能及减轻心室重构.pdfVIP

FULL PAPER Hydrogels www.afm-journal.de A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction Guoqin Chen, Jinliang Li, Mingcai Song, Zhiye Wu, Wenzhu Zhang, Zhongyan Wang, Jie Gao,* Zhimou Yang,* and Caiwen Ou* 1. Introduction Myocardial infarction (MI) remains the major cause of death and disability in the world, and intramyocardial administration of biomaterials (e.g., hydro- Myocardial infarction (MI) remains the gels) along the perimeter of MI region is demonstrated as an effective way major cause of death and disability in the for the treatment of MI. The curcumin has anti-inflammation, antioxidation, world,[1] resulting in left ventricular (LV) negative remodeling and progressive heart and antiapoptosis properties, and nitric oxide (NO) molecules are favorable failure. During or after the early stages of for angiogenesis. This study prepares a mixed component hydrogel capable MI, the loss of myocardium and degrada- of releasing both bioactive curcumin and NO for the treatment of MI. The tion of original extracellular matrix (ECM) study shows that the combinational treatment of curcumin and NO can contribute to progressive ventricular remarkably reduce collagen deposition, improve cardiac function, ameliorate wall thinning of the infarct region