辣椒碱β环糊精体系溶解与渗透的相关性研究-药学;微生物与生化药学专业论文.docxVIP

硕士学位论文 硕士学位论文 辣椒碱，B．环糊精体系溶解与 中文摘要 本研究考察了辣椒碱(CP)在三种倍他环糊精衍生物(HPfICD、SBEpCD、 RMpCD)二元体系中以及CP／HPpCD／水溶性高分子(PVP与HPMC)三元体系 中的溶解性与渗透性。 溶解性研究结果表明：二元体系与三元体系的相溶解度曲线均为AL型，二元 体系中CP的溶解度和稳定常数(Ks)从大到小依次为：RMpCDSBEpCDHPpCD。 CP／HPpCD／高分子三元体系中CP的溶解度和稳定常数均高于CP／I-IPpCD二元体 系；在三元体系中，随着高分子浓度升高，体系的稳定常数趋于升高。 渗透性研究结果表明：对于二元体系，CP渗透速率(J。)从大到小顺序为：HPpCD SBEpCDRMpCD，与二元体系稳定常数的顺序相反；而对于三元体系，两种高 分子的加入使得渗透速率(J。)均低于相应的CP／HPpCD二元体系；在三元体系中， 随着PVP浓度升高，渗透速率(J。)趋于降低，随着HPMC浓度升高，渗透速率(Js) 趋于升高。 从溶解性或稳定性与渗透性的相互关系进行分析，二元体系的稳定常数(磁) 与渗透速率(J。)存在负相关关系，与理论预测结果一致；CP三元体系的稳定常数 虽然高于二元体系，但是其渗透速率低于二元体系；在三元体系中，随着高分子浓 度变化，CP／HPpCD／PVP三元体系的渗透速率(Js)随稳定常数升高而降低，而 CP／HPpCD／HPMC三元体系的渗透速率(J。)随稳定常数升高而升高。 关键词： 辣椒碱；环糊精；水溶性高分子；溶解性；渗透性 permeation permeation of ternary systems with hydroxypropyl—p—cyclodextrin(I-IPpCD)in the presence of water-soluble polymers(PVP and HPMC)． In the solubility studies，both binary and ternary systems showed all AL type of phase solubility diagram，the solubility and the stability constant(KS)of binary systems were in the order：RMl3CDSBEl3CDFIPBCD，and the ternary systems showed higher solubility and stability constant(Kd of CP than CP—FIPpCD binary system，and the the stability constant∞)showed ail increase with the increased concentration of water-soluble polymer both for PVP and HPMC． In the permeation studies，for the binary systems，the permeation flux(Js)were in the order：HPpCDSBEpCDRMI]CD，which is inverse to the stability constant(Ks)of CP／CD binary systems；and for the ternary systems，both PVP and HPMC showed a decrease of the permeation flux(Js)of CP than the CP-HPpCD binary system，The permeation flux(Js)of CP dereseased with the increasing of PVP concentration and increased with the increasing of HPMC concentration． This work demonstrates that there exists a negative correlation between the stability constant(K)and permeation flux(Js)of drug in dmg／CD binary systems；for the ternary systems，the stability constant