慢性阻塞性肺疾病合并肺纤维化的临床研究.docVIP

慢性阻塞性肺疾病合并肺纤维化的临床研究 南华大学附属第二医院 湖南衡阳421001 摘 要 目的针对慢性阻塞性肺疾病合并肺纤维化进行临床研究。方法收集从 2013年9月至2015年9月间我院收集诊断的80例慢性阻塞性肺疾病合并肺纤 维化(PF-COPD)患者作为治疗组和80例慢性阻塞性肺疾病(COPD)患者作为 观察组，对POCD患者与PF—COPD患者的临床症状及体征、CT、血气检查、肺 功能测定等进行回顾性分析。结果80例COPD患者均出现肺气肿，同时有58例 患者出现肺大泡;80例PF-COPD患者均出现了肺气肿，同时胸膜下有蜂窝状影, 其中呈现网络状以及毛玻璃样的有13例，□例患者出现肺大泡。COPD患者以 及PF—COPD患者都有很长的吸烟史，COPD患者表现为呼气性呼吸困难，PF— COPD患者主要表现为呼吸困难加重，病情反复。同时还有肺部湿啰音、杵状指 等相关体征。在用力肺活量(FVC)方面，COPD组患者高于PF—COPD组患者, 两组差异具有统计学意义)lt;0.05)；在第1秒用力呼气量占用力肺活量的百分 比(FEV1% )方面，COPD组患者下降明显高于PF—COPD组患者，两组差异具 有统计学意义(Plt;0.05)；在第1秒用力呼气量(FEV1)方面，两组降幅相差 不大,差异无统计学意义(Pgt；0.05)o结论PF—COPD是由COPD与IPF两种不 同的疾病构成，具有独特的临床特点，患者的临床症状及休征、CT、血气检查、 肺功能测定分析可为临床治疗提供依据 关键词 慢性阻塞性肺疾病；肺纤维化；临床研究； [Abstract]Objective To study the clinical characteristics of chronic obstructive pulmonary disease complicated with pulm on ary fibrosis. Methods from September 2013 to 2015 September in my hospital collection diagnosis of 80 cases of chronic obstructive pulm on ary disease complicated with pulm on ary fibrosis PF-COPD patients as treatment group and 80 cases of chronic obstructive pulmonary disease (COPD) patients as the observation group, of POCD in patients with PF, COPD patients with clin ical symptoms and signs, CT, blood gas exami nation, pulm on ary function determination were retrospectively analyzed. Results 80 cases of patients with chronic obstructive pulmonary disease (COPD) appeared emphysema, and 58 cases of patients with pulm on ary bulla； appeared in 80 patie nts with PF, COPD patients with pulm on ary emphysema, also subpleural have hon eycombi ng is presented in which the network shape and ground glass like a 13 cases, 11 cases of patie nts with pulm on ary bulla. COPD patie nts as well as COPD - PF patie nts have a long history of smoking, COPD patients showed dyspnea，COPD - PF patients mainly for breathi ng difficulties in creased, the condition repeatedly. At the same time and pulm on ary rales, clubbi ng and other related signs. In forced vital capacity (FVC), COPD patients wer