免疫检测 预防和治疗.ppt

Immunotherapy against Cancer -vaccination GVAX (GMCSF gone modified tumor vaccine，瘤苗) Glenn Dranoff HMS DFCI 自体肿瘤细胞经过基因修饰表达后，体外灭活进行皮下接种 James P. AllisonHHMI MSKC Immunotherapy against Cancer ----blocking of CTLA-4 + GVAX Blocking antibody against CTLA-4 Anti-CTLA4 Immunotherapy against Cancer ----DC vaccination + lysis Acid elution synthesis extraction mRNA Antigen peptide Native peptide Cell lysate Tumor cell --Adoptive immunotherapy TILs 3. BRMs （biological response modifiers） and Immunosuppressors Type of BRM Examples Major Effect Bacteria Products BCG (卡介苗), C. Parvum (短小棒状杆菌)， m