贲晓明Lecture-Updated中文版-公开课件.pptVIP

乳铁蛋白Lactoferrin基础研究 临床应用Research Progress Clinical Application 双歧杆菌 （标记 1μm） Bifid bacteria (Bar:1μm) 乳酸杆菌（标记 2μm） Lactobacillus （Bar 2μm） Fe++ Zn++ 会议要点 Program The Conference cover the following main topics: Lactoferrin structure – Ligands receptors Lactoferrin – Iron metabolism Lactoferrin – Prebiotic Probiotic Lactoferrin – Anti-microorganisms 乳铁蛋白 – 抗病菌、抗病毒、抗霉菌 Lactoferrin – Immuno-modulating Lactoferrin – Bone growth Lactoferrin applications – Food drug (A). BALB/c mice challenged with a sub-lethal dose of E.coli demonstrate severe jejunal tissue destruction at 4 days post infection (B). Parenchyma from mice pretreated with lactoferrin (1 mg/mouse, intravenous, 4 hours prior to challenge) remained intact 会议要点 Program The Conference cover the following main topics: Lactoferrin structure – Ligands receptors Lactoferrin – Iron metabolism Lactoferrin – Prebiotic Probiotic Lactoferrin – Anti-microorganisms Lactoferrin – Immuno-modulating 乳铁蛋白 – 免疫调节-抗过敏、抗氧化、抗肿瘤 Lactoferrin – Bone growth Lactoferrin applications – Food drug 过敏历程（Allergy march） 过氧化损伤 / SIRS Lipid peroxidation and DNA damage LF * 母乳三大营养素 蛋白质 10-15g/L 脂肪 35-40g/L 碳水化合物 65-70g/L 长链多不饱和脂肪酸(LCPUFA) 花生四烯酸(AA ,C20∶4) 200 mg/ L 二十二碳六烯酸(DHA , C22∶6) 100 mg/ L 低聚糖(Oligosaccharides) 初乳-低聚糖10～20 g/ L 成熟乳-低聚糖5～10 g/ L 半乳糖低聚糖( GOS) = 低聚糖 1/2 乳铁蛋白(Lactoferrin, LF) 初 乳-乳铁蛋白 LF 4～8 g/ L 成熟乳-乳铁蛋白 LF 2～4 g/ L 会议要点 Program The Conference cover the following main topics: Lactoferrin structure – Ligands receptors 乳铁蛋白 – 结构 功能 Lactoferrin – Iron metabolism Lactoferrin – Prebiotic Probiotic Lactoferrin – Anti-microorganisms Lactoferrin – Immuno-modulating Lactoferrin – Bone growth Lactoferrin applications – Food drug Figure 1. Effect of heating on denaturation of lactoferrin. 会议要点 Program The Conference cover the following main topics: Lactoferrin structure – Ligands receptors Lactoferrin – Iron metaboli