Lymphocytes七年制教学课件.ppt

* * * * * * * * * * * DiGeorge迪格奥尔格综合征即先天性无胸腺或发育不全 * * * * * * * Features of NK Cell-Mediated Cytotoxicity No priming, memory, specificity No MHC Restriction Response amplified by certain cytokines IFN-α IFN-β IL-12 IL-15 IL-18 Control of NK-cell activity by KIR and KAR * * * * * * * The numbers cited refer to B-cell development in the mouse, but the overall principles apply to humans as well * C区的基因在V区基因的下游，1~9个，如H的C基因有9个功能性基因。 BCR/Ig的重链V区基因 是由三种胚系基因片段：V、D、J拼接而成，轻链V区基因 是由V、J两个基因片段拼接成的。互补决定区CDR1+CDR2←V基因片段，大部CDR3←D， 其余CDR3←J 。 * * * 类似于TCR-CD3 * * * CD44 molecules: T cell recirculation