三种不同剂量的盐酸帕罗诺司琼对预防小儿斜视术后恶心呕吐的研究.docVIP

作者单位：200031 复旦大学附属眼耳鼻喉科医院麻醉科 通信作者：谭放，tanfang1977@ 尊敬的编辑 遵照专家的意见,文章已经做了如下修改 “文章的病人一般资料中没有列出性别，对于术后恶心呕吐，性别是非常重要因素，应该加以分析。” 回答：我们已经增加了患者的性别资料，见表1。 “图1列的是病人生存率，这个提法在本文中是否欠妥？” 回答：我们已经将生存率改为未发生治疗失败的患者比例 ；图1标题改为两组患者的治疗失败时间曲线。 . 帕洛诺司琼与格拉司琼预防眼球摘除加义眼植入术后恶心呕吐的效果比较 胡潇 谭放 李文献 Comparison of effect of palonosetron and granisetron in preventing postoperative nausea and vomiting for patients undergoing orbital hydroxyapatite implant surgery 【摘要】 目的 比较两种不同剂量的帕洛诺司琼与格拉司琼对预防患者眼球摘除加义眼植入手术后恶心呕吐的效果及其安全性。 方法 择期全麻下行眼球摘除加义眼植入手术的患者80名，ASA Ⅰ-Ⅱ级，年龄18-70岁，随机分为两组，P组：帕洛诺司琼2.5μg/kg(n=40),G组：格拉司琼40μg/kg(n=40)。均予麻醉诱导前5min静注不同剂量的帕洛诺司琼和格拉司琼，在预设的时间点观察恶心和呕吐的严重程度，评估完全缓解率，并记录各组的治疗失败时间。 结果 两组患者在0-4h,4-24时间段的恶心和呕吐评分存在显著差异（P0.05），此外，在24-48h内G组的恶心评分显著高于P组（P0.05）；除了24-72h，P组的完全缓解率均高于G组（P0.05）；并且P组的治疗失败时间明显长于G组（P0.05）。 结论 2.5μg/kg的帕洛诺司琼比40μg/kg的格拉司琼对于预防术后恶心呕吐更有效。 【关键词】 帕洛诺司琼；格拉司琼；PONV Abstract Objective: To compare the effect of 2 different doses of palonosetron and granisetron of preventing postoperative nausea and vomiting in patients undergoing orbital hydroxyapatite implant surgery. Method:80 patients(ASA Ⅰ-Ⅱ) aged between 18 and 70 years old ,and scheduled for orbital hydroxyapatite implant surgery were enrolled in this study.They were assigned into two groups randomly:Group P(palonosetron 2.5μg/kg) and Group G(granisetron 40μg/kg).Each group contained 40 patients who received palonosetron or granisetron 5 minutes before induction fo anaesthesia.The severity of nausea and vomiting ,complete response(CR),and time to treatment failure(TTF) were evaluated during the postoperative time intervals . Result:The severity of nausea and vomiting during the intervals of 0-4h and 4-24h was significantly different between Group P and Group G (P0.05）.Scores of nausea during 24-48h were also declined in Group P compared with Group G(P0.05）.CR of Group P was stasticly higher than Group G during any intervals except 24-72h(P0.05). TTF was significantly longer in Group P than in Group G(P0.05) Conclusion:Compared with