等级医院评审解读与准备.ppt

* 力克雷?贴剂是一种透皮贴剂，每时每刻一定量的尼古丁逐渐通过皮肤吸收进入人体 有两类贴剂：24小时贴剂(每天早晨更换）。16小时贴剂（夜间揭除），当使用者睡眠时没有尼古丁释放。 贴剂的最大益处是方便使用，尼古丁剂量控制谨慎，依从性高 然而，贴剂治疗没有戒烟的行为支持。 * * Slide 16 * Key Point Data from multiple trials have outlined the efficacy of specific antidepressant therapy (bupropion SR, nortriptyline) for quitting smoking. Background Multiple trials have been conducted investigating antidepressant therapy, including bupropion SR SR, nortriptyline, and several selective serotonin-reuptake inhibitors, for quitting smoking. A Cochrane review of the literature found 24 trials studied the use of bupropion SR therapy either alone or in combination with other methods (eg, nicotine replacement therapy [NRT]). Analysis of data from 19 trials that investigated Bupropion SR monotherapy resulted in an OR of 2.06 for success in quitting smoking. Two trials of bupropion SR plus NRT patch treatment compared with placebo yielded an OR of only 1.60. The combined OR for all trials of bupropion SR versus placebo was 1.99.1 Compared with bupropion SR, fewer trials have been conducted with nortriptyline (24 vs 6, respectively), and in the whole of the published literature, it has only been tested for quitting smoking in approximately 500 smokers.1,2 A Cochrane analysis of all available data revealed an OR of 2.14 for quitting smoking. This increased slightly to 2.79 when only the trials of nortriptyline monotherapy were included in the analysis.1 There is limited or no evidence of long-term benefit with other antidepressants including the monoamine oxidase inhibitor, moclobemide, the atypical, venlafaxine, or the selective serotonin reuptake inhibitors, fluoxetine, sertraline, and paroxetine.1 References 1. Hughes J, Stead LF, Lancaster T. Antidepressants for smoking cessation. Cochrane Database Syst Rev. 2004;(4):CD000031. 2. Hughes JR, Stead LF, Lancaster T. Nortriptyline for smoking cessation: a review. Nicotine Tob Res. 2005;7:491–499. Hughes/pg 42-45/figures 1 and 3/abstract 1/Hughes/ p. 1/ abstract; p.