肠破裂合并腹腔感染患者肠内营养支持的临床研究-中国医药指南.docVIP

当归四逆汤对慢性荨麻疹患者的临床疗效分析 陈坚 （ 山东兖矿新里程总医院，山东 邹城 273500 （山东邹城 ） 【摘要】目的 探讨中药当归四逆汤对慢性荨麻疹患者血清炎性反应、免疫机制与临床疗效及生活质量影响。方法 选择2017年12月至～2018年10月诊断慢性荨麻疹180例，随机数字表法分为中药组与对照组。对照组患者给予咪唑斯汀缓释片10 mg/（次·d）/天，中药组在对照组基础上给予加用当归四逆汤口服治疗，治疗时间8周。治疗前后，流式细胞仪检测外周静脉血CD4+T淋巴细胞亚群、计算Th1/Th2、Th17/Treg比值变化。免疫比浊法检测血清超敏C反应蛋白、酶联免疫吸附法检测血IL-17，免疫化学法检测血浆D-二聚体，比较2组患者荨麻疹严重程度评分（UAS7）、皮肤病生活质量指数评分（DLQI）变化与临床疗效。 结果 治疗后，2组患者外周血Th1/Th2升高，Th17/Treg比值降低，血清hs-CRP、IL-17、D-二聚体水平下降，症状严重程度评分降低、皮肤病生活质量指数评分改善、临床疗效提高。其中，中药组改善幅度优于对照组，组内前后比较与治疗后组间比较差异有统计学意义（P＜0.05）。结论 中药当归四逆汤可以显著减轻慢性荨麻疹患者临床症状，改善患者生活质量，提高临床疗效。分析机制与其下调体内炎性反应、纠正凝血机制紊乱与免疫失衡有关。 【关键词】荨麻疹；超敏C反应蛋白；血浆D-二聚体；慢性；中药；疗效 中图分类号：R758.24 文献标识码：B Clinical Eeffect of Danggui Sini Decoction on Ppatients with Cchronic Uurticaria CHENhen J jian (Shandong Yankuang New Mileage General Hospital, Zoucheng yankuang new journey general hospital 273500, China) [Abstract] Objective To investigate the effect of Danggui Sini Decoction on serum inflammatory response,immune mechanism,clinical efficacy and quality of life in patients with chronic urticaria. Methods 180 cases of chronic urticaria diagnosed from December 2017 to October 2018 were selected and randomly divided into Chinese medicine group and control group. The patients in the control group were given mizolastine sustained-release tablets 10 mg/time/day, while the patients in the Chinese medicine group were given Danggui Sini Decoction on the basis of the control group for eight weeks. Before and after treatment, CD4+T lymphocyte subsets in peripheral venous blood were detected by flow cytometry, and the ratio of Th1/Th2 and Th17/Treg was calculated. Immunoturbidimetry was used to detect serum hypersensitive C-reactive protein,enzyme-linked immunosorbent assay was used to detect serum IL-17, and immunochemistry was used to detect plasma D-dimer. The changes of urticaria severity score (UAS7), dermatosis quality of life index (DLQI) and clinical efficacy were compared between the two groups. Results Af