系统性红斑狼疮血瘀证与PFB、ACA等免疫指标的相关分析.pdfVIP

但不具有线性回归关系（P ＞0.05 ）。⑥补体 C3、补体 C4 与 PFB 呈 正向直线相关（P0.05 ），并具有线性回归关系（P ＜0.05 ）。⑦CIC、 ACA 与 PFB 之间无直线相关（P ＞0.05 ）。 结论：①SLE 患者血瘀证与补体 C3、补体 C4、CIC、ACA 等免疫学 指标及病程和病情活动度存在相关性，与备解素 B 因子无相关关系。 ②补体 C3、补体 C4、CIC、ACA 等免疫学指标可能是导致 SLE 血瘀 证的重要原因或现代免疫学基础。③补体 C3、补体 C4、CIC、ACA 等免疫学指标及病程和病情活动度可以作为 SLE 血瘀证辨证的参考 指标。④瘀血阻滞是 SLE 的主要病机之一，提示在临床治疗时，应 在传统辨证施治的基础上，佐以活血化瘀的治疗。 关键词：系统性红斑狼疮 血瘀证 备解素 B 因子 抗心磷脂抗体 补 体 II 万方数据 Abstract Objective: To explore the immunological basis of blood stasis syndrome of systemic lupus erythematosus, analysing the relativities of blood stasis syndrome and the clinical data, such as properdin B factor in the peripheral blood, complement 3, complement 4, anti-cardiolipin antibodies and circulating immune complexes, and culminately to provide a reference for the syndrome differentiation and treatment. Methods:According to ACR classification criteria for SLE and the 2002 version of “clinical research guidelines for Chinese medicine” for the syndrome differentiation of blood stasis, seventy patients were enrolled into the trial, of which 8 male, 62 female. The major outcome variables were properdin B factor in the peripheral blood, complement 3, complement 4, anti-cardiolipin antibodies and circulating immune complexes. The scores of the blood stasis syndrome and SLE disease activity index were collected. SPSS 21.0 statistical software was used for data processing to evaluate the the relativities of blood stasis syndrome and the clinical data. Calculate the