根据PKPD理论合理使用抗菌药南京.pptVIP

体温小于等于37.9度，白细胞恢复到5000-10000，有以上两点同时临床症状好转（脓痰减少）认为治愈，细菌根除不作为治愈标准（因为不重复查） We caution against extrapolating these data to single daily dosing regimens with aminoglycosides since the majority of our patients were dosed two to three times daily, and thus, optimal Cmax/MIC ratios were obtained multiple times within a 24-h interval (iii) Toxicity evaluation. Aminoglycoside-associated nephrotoxicity was de- ?ned as a rise in the serum creatinine concentration of $0.5 mg/dl if the initia serum creatinine concentration was ,3.0 mg/dl or a rise of 1.0 mg/dl if the initia serum creatinine concentratio