稀土及其配合物抗肿瘤活性的研究进展.docVIP

稀土配合物抗肿瘤活性的研究进展 刘燕1，周轶平1，罗敏1，李玛琳2 (1．昆明医科大学，云南 昆明 650500；2.云南中医学院，云南 昆明 650500） 摘要:大量研究表明，稀土具有一定的抗肿瘤活性，稀土与配体形成配合物后其抗肿瘤活性强于配体。目前，国内外研究安全、有效、可控(可控是什么意思？是什么可控？)的稀土配合物的抗肿瘤药物已经成为热点，已研究出多种稀土配合物并对其进行抗肿瘤机制分析。本文将对已研究出的多种稀土配合物进行分类，并对其抗肿瘤机制进行归纳、总结。 关键词: 稀土配合物； 抗肿瘤； 机制 The Advance in the Research on the Antitumor Activity of Rare Earth Complexes LiuYan1),ZhouYi-ping1),LuoMin1),LiMa-lin2) (1) Kunming Medical University, Kunming Yunnan 650500;2) Yunnan University of Traditional Chinese Medicine, Kunming Yunman 650500) [Abstract] Studies have showed that the rare earths have some antitumor activities. The rare earth complexes has exhibited stronger antitumor activity than their ligands. Researchers have developed a variety of rare earth complexes which have the features of safetylow toxicity, effectivity high efficacy and control？. The rare earth complexes in vitro and vivo antitumor activies and mechanisms of rare earth complexestheir antitumor activies have been studied. This review will classifypaper summarize the synthesis of rare earth complexes and summarize thetheir antitumor mechanisms of their antitumor activites. [Key words] Rare earth complex; Antitumor activity; Mechanism 1975年, Anyhilelri ADDIN EN.CITE EndNoteCiteAuthorAnghileri/AuthorYear1975/YearRecNum2/RecNumDisplayTextstyle face=superscript[1]/style/DisplayTextrecordrec-number2/rec-numberforeign-keyskey app=EN db-id=2ezfsvf2j2xvdye5xebv0srlatafwdpa9pxw2/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorAnghileri, L. J./author/authors/contributorstitlestitleOn the antitumor activity of gallium and lanthanides/titlesecondary-titleArzneimittelforschung/secondary-title/titlesperiodicalfull-titleArzneimittelforschung/full-title/periodicalpages793-5/pagesvolume25/volumenumber5/numberedition1975/05/01/editionkeywordskeywordAnimals/keywordkeywordAntineoplastic Agents/ therapeutic use/keywordkeywordCalcium/metabolism/keywordkeywordFemale/keywordkeywordGallium/pharmacology/ therapeutic use/k