乌司他丁对高糖作用下大鼠腹膜间皮细胞IL-15CTGF及MDA表达的影响.DOCVIP

PAGE PAGE 6 心脏骤停患者心肺复苏成功后血清GDF-15水平变化的临床意义基金项目：承德市科技技术研究与发展计划项目 基金项目：承德市科技技术研究与发展计划项目 作者单位：河北省承德市中心医院急诊科（河北承德，067000） 通信作者：姜润东, Email：jiangrundongcd@163.com 姜润东 任长安 周景霞* （河北省承德市中心医院， 河北 承德 067000） 摘要 目的 探讨心脏骤停患者心肺复苏成功（CPR）后不同时间点血清生长分化因子-15（GDF-15）水平变化及与近期临床预后的关系。 方法 分别检测102例CPR患者CPR后即刻、12h、24-48h的血清GDF-15水平，根据血清GDF-15升高时间分为3组，A组：CPR后即刻、12h、24-48h血清GDF-15水平一直小于1200ng/L， B组：CPR后12h 和24-48h GDF-15水平持续升高，且一直大于1200ng/L；C组： CPR后12h 和24-48h GDF-15水平持续升高，但24-48h较12h时降低。随访6个月后三组患者的死亡情况。 结果 　随访6个月，B组患者的死亡情况明显高于A组与C组； C组患者死亡情况稍高于A组。 结论 CPR过程中，GDF-15可在心室早期激活，并且呈动态变化，这对机体是一种保护性反应。但是，CPR后，如果患者血清中GDF-15持续升高，提示患者出现了心功能不全，患者预后会很差。临床上为了改善CPR患者近期预后，治疗上应积极改善心功能不全，提高心排出量，改善重要脏器的血液灌注。 关键词 心肺复苏；生长分化因子-15；心力衰竭；近期临床预后。 Change of GDF-15 in peripheral blood in different time after cardiopulmonary resuscitation and the recent clinical prognosise JIANG Run-dong,REN Chang-an,ZHOU Jing-xia* （The emergency department of Chengde city center hospital , Hebei province , Chengde 067000,China Corresponding auther:JIANG Run-dong, Email:jiangrundongcd@163.com） Abstract Objective To explore the relationship between the level of growth defferentiation factor-15 in peripheral blood and the Recent clinical prognosis of cardiopulmonary resuscitation(CPR) . Methods A total of 102 victims with sudden cardiac arrest who received CPR were divided into three groups．The victims who the GDF-15 levels has been less than 1200ng/L into Group A．those who the GDF-15 levels at the time of 24-48h after CPR are higher than the time of 0h and 12h after CPR into Group B，and those who the GDF-15 levels at the time of 24-48h after CPR are lower than the time of 0h and 12h after CPR into Group C．Follow-up 102 cases with ACS 6 months of mortality incidence. Results 6 months of mortality incidence of Group B are obviously higher than that of group A and group C; 6 months of mortality incidence of Group C are slightly higher than that of group A . Conclusions The expression of GDF-15 ac