急性髓系白血病个体化治疗新进展 浦西洲际酒店.pptx

急性髓系白血病个体化治疗新进展;何谓个体化治疗？;Cancer Discov; 3(12);1416–29. ?2013 AACR.;;Cancer Discov; 3(12);1416–29. ?2013 AACR.;基因分层;Meta-analysis of Papaemmanuil et al 2016 data for broad patterns of genomic instability in AML shows that ~20% of patients with AML were defined according to fusion genes, 31% by chromosomal aneuploidies (to include at least 1 aneuploidy), 46% by gene mutations only (in the absence of gene fusions and chromosomal aneuploidies), and 3% with no events.;;;Neurofibromin 1 gene Mutations Are Recurrent Events in Adult Patients with Acute Myeloid Leukemia (AML), Associate with Poor Outco