Ester- and Amide Hydrolysis in Near Critical Water外文学习材料.pdfVIP

Application Note Ester- and Amide Hydrolysis in Near Critical Water Introduction General Reaction Procedures: The use of simple water as solvent in organic 1) 7 mmol (1.05 g, 1mL) ethyl benzoate suspended synthesis in the meaning of Green Chemistry in 15 mL H2O applications has attracted considerable interest in the last years. Water changes its physical properties 2) 5 mmol (605 mg) benzamide suspended in 15 ml H2O at higher temperatures, acts like a pseudo-organic solvent and can serve as acidic or basic catalyst in the so-called near-critical stadium at temperatures Step Temp [°C] Ramp [min] Hold [min] Fan above 250°C and pressures 40 bar. Whereas with classical thermal heating toilsome autoclave 1 295 8 various 0 systems have to be applied to reach these conditions, the Synthos 3000 enables easy access 2 0 0 20 3 to near-critical water (NCW) conditions offering easy-to-handle high pressure containers. The quartz vessels can be treated up to 4 h at conditions of 80 bar and 300 °C. Herein we present as model Optimization: reactions the hydrolysis of ethyl benzoate and benzamide, respectively, applying only water to 1) Hydrolysis of ethyl benzoate at 295 °C furnish benzoic acid.