2011-PEG-based hydrogels with tunable degradation characteristics to control delivery英文学习资料 .pdfVIP

Acta Biomaterialia 7 (2011) 959–966 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: /lo cate/actabiomat PEG-based hydrogels with tunable degradation characteristics to control delivery of marrow stromal cells for tendon overuse injuries Yongzhi Qiu a, Jeremy J. Lim a, Larry Scott Jr. a, Ryan C. Adams a, Hieu T. Bui a, Johnna S. Temenoff a,b,⇑ a W.H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332, USA b Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA a r t i c l e i n f o a b s t r a c t Article history: Marrow stromal cells (MSCs) have been suggested as a means to improve healing in tendon overuse inju- Received 21 July 2010 ries (tendinopathy), but optimal delivery methods for these cells have yet to be determined. In this study Received in revised form 28 September novel degradable hydrogels based on oligo(poly(ethylene glycol) fumarate) (OPF) and acrylated poly(eth- 2010 ylene glycol)–dithiothreitol (Ac PEG–DTT) with tunable degradation times ranging from a few days to Accepted 1 November 2010 Available online 4 November 2010 1 month were synthesized as MSC carriers for tendon overuse injuries. The addition of higher amounts of OPF or higher dithiothreitol (DTT) concentrations resulted in enhanced fold swelling and degradation.