Autophagy mediates degradation of nuclear lamina英文学习资料 .pdfVIP

LETTER doi:10.1038/nature15548 Autophagy mediates degradation of nuclear lamina 1 1 1 2 3 1 4 1 Zhixun Dou , Caiyue Xu , Greg Donahue , Takeshi Shimi , Ji-An Pan , Jiajun Zhu , Andrejs Ivanov †, Brian C. Capell , 1 1 3 5 6 2 Adam M. Drake , Parisha P. Shah , Joseph M. Catanzaro , M. Daniel Ricketts , Trond Lamark , Stephen A. Adam , 5,7,8 3 6 2 4 1 Ronen Marmorstein , Wei-Xing Zong , Terje Johansen , Robert D. Goldman , Peter D. Adams Shelley L. Berger Macroautophagy (hereafter referred to as autophagy) is a cata- lipidation (Extended Data Fig. 1h–j). Together, these data suggest that bolic membrane trafficking process that degrades a variety of LC3 directly interacts with lamin B1, and that LC3 lipidation facilitates cellular constituents and is associated with human diseases1–3. this interaction, possibly by tethering LC3 to the inner nuclear mem- Although extensive studies have focused on autophagic turnover of brane where the interaction with nuclear lamina occurs. cytoplasmic materials, little is known about the role of autophagy in e a n b