二芳基硫代草酰胺与1二溴乙烷的反应的研究StudyontheReaction.pdf

2005 年第 25 卷 有 机 化 学 Vol. 25, 2005 第 7 期, 838～841 Chinese Journal of Organic Chemistry No. 7, 838～841 ·研究简报· N,N-二芳基硫代草酰胺与 1,2-二溴乙烷的反应的研究 刘玮炜*,a,b 赵跃强 a 濮月庆 a 许瑞波 a 胡宏纹 b a ( 淮海工学院化工系 连云港 222005) (b 南京大学化学系 南京 210093) 摘要 以 N,N-二芳基二硫代草酰胺与 1,2-二溴乙烷进行 S 烷基化反应, 合成了一系列 2,3-双芳基亚氨基- 1,4-二硫杂环 己烷, 反应在 4 h 内完 , 产率 52%～62%. 产物结构经元素分析, IR, 1H NMR 及 MS 表征, 并以单晶 X 射线衍射分析 进一步确证. 关键词 N,N-二芳基取代二硫代草酰胺; 1,2-二溴乙烷; 2,3-双芳基亚氨基- 1,4-二硫杂环己烷; 单晶; X 射线衍射 Study on the Reaction of N,N-Diaryldithiooxamides with 1,2-Dibromoethane LIU, Wei-Wei*,a,b ZHAO, Yue-Qianga PU, Yue-Qinga XU, Rui-Boa HU, Hong-Wenb a ( Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China) (b Department of Chemistry , Nanjing University, Nanjing 210093, China) Abstract A series of 2,3-biarylimino-1,4-dithiacyclohexane compounds were synthesized by the sufur- alkylation of N,N-diaryldithiooxamide with 1,2-dibromoethane in the presence of bases. The reactions were completed in 4 h and the yields were 52%～62%. The structures of the products were established by ele- 1 mental analysis, IR, H NMR, MS spectra and X-ray diffraction analysis. Keywords N,N-diaryldithiooxamide; 1,2-dibromoethane; 2,3-biarylimino-1,4-dithiacyclohexane; crystal; X-ray diffraction 有机硫化物的研究是目前化学学科的研究热点之 们的合成及应用尤其是在生物活性方面的研究非常活 一, 用它作为中间体已合成了许多其它方法难以合成的