中山大学生物化学课件.pptVIP

Mechanism of ABC transporters (1) Mechanism of ABC transporters (2) Multidrug resistance: Human ABC transporters §10.4.3 Pumps Pumps are enzyme-like (different from channels) proteins that utilize energy to move solutes across membranes characteristic Vmax and Km for its solute primary active transporters ATP dependent pumps Light dependent pumps V-type P-type F-type ABC family Bacteriorhodopsin Ca2+ pump Na+-K+ pump Bacteriorhodopsin 反式视黄醛 顺式视黄醛 Bacteriorhodopsin:retinal Light Lys216 covalent with retinal water Cytosol Extracellular Structure of Bacteriorhodopsin Mechanism of Bacteriorhod