高级生物化学蛋白质的三维结构.ppt

第三节 蛋白质的三维结构;Hierarchy of Protein Structure;影响蛋白质的三维结构形成的因素： 1、与溶剂分子（通常是水） 的相互作用 2、溶剂的PH值和离子构成 3、蛋白质的氨基酸序列 （重要因素） 天然蛋白质只有一种或几种构象，是热力学上最稳定的;; 蛋白质构象;共价键;蛋白质分子中的共价键与非共价键;Covalent disulfide bonds ;Hydrogen bonds;A charged group is able to attract another group of opposite charges. (acid-base) ;Interactions that determine the tertiary structure of proteins;Forces that stabilize protein structure; An asymmetric electronic charge around an atom causes a similar asymmetry around its neighboring atoms. The attraction between a pair of atoms increases as they come c