北医免疫课程免疫信息学.pptVIP

I. 免疫信息学概要 王平章 北京大学医学部免疫学系 2014年10月24日 Immunoinformatics 免疫信息学( Immunoinformatics) 是生物信息学的分支学科，是计算机科学与免疫学相结合的交叉学科，重点是利用计算机技术开展免疫学的生物信息学分析和计算。 Immunoinformatics Computation immunology The field’s main aim is to convert immunological data into computational problems, solve these problems using mathematical and computational approaches and then convert these results into immunologically meaningful interpretations. High throughput+computer ‘Immunoinformatics’一词来源 A term I coined with Vladimir Brusic in 2002 to a meeting spon-sored by the Novartis Foundation that was held in London in 2002 under the title “Immunoinformatics: Bioinformatic strategies for better understanding of immune function”. That meeting brought together for the first time experts from a wide array of different disciplines including immunology, bioinformatics and mathematical modeling, to discuss how we might help to move immunology research into the post-genomics world. 免疫信息学国际会议通常主题 Epitope analysis and prediction (T-cell, B-cell epitopes) MHC-peptide binding site analysis and prediction Analysis and prediction of minor histocompatibility antigens Vaccine design/In silico vaccination Allergenicity/Allergy prediction Predictive models for organ transplantation Immunoinformatics databases, Knowledge bases, Ontologies Computational modeling of immune system Immunogenomics Immunomics Structural immunoinformatics Artificial immune systems and other biologically-inspired paradigms Multi-agent based modeling of immune response Gene expression changes in adaptive immune response Comparative approaches to immunology 免疫识别与应答是免疫学的核心问题 B-cell epitopes continuous/linear epitopes ~10% discontinuous/conformational epitopes ~90% 表位预测与疫苗设计 T/B-cell-immunome-discovery flow chart II. 基本知识介绍(核酸、蛋白质、信息技术的应用) 2014年10月24日 信息学的基本过程 强调信息学的工具性 掌握基本知识 学会如何查找与挖掘数据 强调信息学的实践性 常使用，常关注 强调信息学的学科交叉性 计算机、统计、生物知识 Linux+R+PERL三元组合 强调信息的快速发展性 新技术，新方法 数据的快速更新 强调信息的高通量特性 大数据时代 核酸(nucleic acid) 基本组成单位：核苷酸(nucleotide)，包括： d