帕金森与糖尿病关系.pptVIP

Meta-analysis and pooled RRs of PD in diabetic participants from prospective cohort studies (Forrest plot A [A], association found for fully adjusted estimates; Forrest plot B [B], association found for fully adjusted estimates obtained after the exclusion of participants who had vascular disease at baseline and/or who developed them during the follow-up). d.f., degrees of freedom. . Potential sources of heterogeneity between studies were assessed using Cochran’s Q and I2 statistics. To compensate for potential between-study heterogeneity, we calculated a pooled RR or OR using a random-effect model (DerSimonian-Laird method); otherwise, we used fixed effect models. All analyses were performed using STATA 11 (StataCorp, College Station, TX), establishing the level of significance at a two-tailed P value of 0.05. * Forrest plot (pooled OR) for the association between pre-existing diabetes and PD in case-control studies: plot A (A), primary analysis (all studies); plot B (B), sensitivity analysis (studies providing estimates adjusted for BMI). I-V, inverse variance fixed-effect model; D+L, DerSimonian-Laird random-effect model; d.f., degrees of freedom. * 帕金森病与糖尿病的关系 PD vs DM 早在1974年，Ivan J. Lipman等人已注意到,帕金森病人中糖耐量异常的患者占了很大比例，并且与年龄、病程、和疾病分期无明显关联。 近年来糖尿病与阿尔茨海默病（AD）和痴呆的研究为二者的相互关系提供了明确证据，提示神经系统变性疾病与糖尿病有不可忽视的联系。 Ivan J. Lipman?, Glucose intolerance in parkinsons disease Journal of Chronic Diseases Volume 27, Issues 11–12, December 1974, Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004; 61:661–666 帕金森综合症 糖尿病可以引起多种并发症，长期血糖未得到良好控制可引起神经病变和微血管病变，可诱发血管性帕金森病；糖尿病急性并发症，如酮症酸中毒、高渗昏迷等神经系统损害也可引起继发性帕金森病，即帕金森综合症。 Foltynie T, Barker R, Brayne C. Vascular parkinsonism:a review of the precision and frequency of thediagnosis. Neuroepidemiology 2002; 21: 1–7 周 蕾 等，糖尿病酮症昏迷心肺复苏后致帕金森综合征报告 《吉林医学》2010年6月31卷11期 流行病学调查 正相关 负相关或无关 发表时间，2008年 样本量，7,274人 国家，UK 病例对照研究：选择1994-2005年间首次