乳腺癌基因分型与患者临床病理及预后的关系-肿瘤防治研究.PDF

752 2018 45 10  Cancer Res Prev Treat,2018,Vol.45,No.10 · · 肿瘤防治研究 年第 卷第 期 doi:10.3971/j.issn.1000-8578.2018.17.1658 · · 临床研究 乳腺癌基因分型与患者临床病理及预后的 关系 1,2 3 1 4 4 1,4 陈美慧 ，钟媚共，蒋旭，刘琼茹，李荣岗，张鑫 Correlation of Genotypes with Clinicopathological and Prognostic Characteristics of Breast Cancer Patients CHEN Meihui1,2 3 1 4 4 1,4 , ZHONG Meigong , JIANG Xu , LIU Qiongru , LI Ronggang , ZHANG Xin 1. Clinical Experimental Center, Jiangmen Central Hospital, Jiangmen 529030, China; 2. Laboratory Department, Central Hospital of Guangdong Nongken, Zhanjiang 524002, China; 3. Pharmacy Department, Jiangmen Maternity and Child Health Care Hospital, Jiangmen 529030, China; 4. Pathology Department, Jiangmen Central Hospital, Jiangmen 529030, China Corresponding Author: ZHANG Xin, E-mail: zhangx45@ Abstract: Objective To investigate the correlation of genotypes with clinicopathological and prognostic characteristics of breast cancer patients. Methods Breast cancer microarray datasets were downloaded from ArrayExpress, and integrated by Affy program and YuGene packages, named as AE-meta dataset. Breast cancer RNA sequencing data was downloaded from the cancer genome atlas (TCGA), named as TCGA breast cancer dataset. The absolute intrinsic molecular subtyping (AIMS) package was used to classify breast cancer subtypes. The correlation of genotypes with clinicopathological and prognostic data of breast cancer patients was analyzed. Results The LumA patients were more common in older women with smaller- sized tumors, better differentiation and less lymph node invasion.