利尿药和降血糖药介绍.pptVIP

Mechanism of Action The major site of action of these compounds is in the distal tubule, where these drugs compete for the chloride binding site of the Na+-C1- symporter and inhibit the reabsorption of sodium and chloride ions. They also inhibit the reabsorption of potassium and bicarbonate ions but to a lesser degree. Structure-activity Relationship The hydrogen atom at the 2-N is the most acidic. These acidic protons make possible the formation of a water-soluble sodium salt. An electron-withdrawing group is necessary at position 6 for diuretic activity. Replacement or removal of the s