牙龈卟啉单胞菌与口腔鳞状细胞癌关系的研究进展-华西口腔医学杂志.pdf

33 6 2015 年 12 月 华西口腔医学杂志 第 卷 第 期   West China Journal of Stomatology Vol.33 No.6 Dec. 2015 •651• [文章编号] 1000-1182(2015)06-0651-05 ·综述· 牙龈卟啉单胞菌与口腔鳞状细胞癌关系的研究进展 吴武超 吴亚菲 赵蕾 口腔疾病研究国家重点实验室 华西口腔医院牙周病科（四川大学），成都 610041 [摘要] 目前已有大量证据支持慢性感染性炎症与癌症的形成有关，慢性牙周炎可能促进了头颈部鳞状细胞癌的发 生发展。口腔鳞状细胞癌是口腔颌面部最常见的恶性肿瘤，而牙龈卟啉单胞菌是口腔中引发慢性感染性炎症反应最 重要的牙周致病菌；随着分子生物学技术的发展，牙龈卟啉单胞菌与口腔鳞状细胞癌之间的关系也越来越受到重 视。本文就牙周病与口腔颌面部肿瘤，牙龈卟啉单胞菌与口腔鳞状细胞癌的相关性及可能致病机制在口腔医学领域 的研究进展作一综述，以期为临床提供帮助。 [关键词] 口腔鳞状细胞癌； 慢性牙周炎； 牙龈卟啉单胞菌 [中图分类号] R 780.2 [文献标志码] A [doi] 10.7518/hxkq.2015.06.021 Research progress on the relationship between Porphyromonas gingivalis and oral squamous cell carcinoma Wu Wu- chao, Wu Yafei, Zhao Lei. (State Key Laboratory of Oral Diseases, Dept. of Periodonticis, West China Hospital of Stoma- tology, Sichuan University, Chengdu 610041, China) [Abstract] Substantial evidence supports the relationship between chronic inflammation and cancer development. Numerous studies suggest that chronic inflammatory disease, such as periodontitis, contributes to head and neck squamous cell carcinoma development. Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial regions. Porphyromonas gingivalis, one of the most important pathogens in association with periodontal disease, might have a potential correlation with OSCC. Along with the development of molecular biological techniques, the association between Porphyromonas gingivalis and OSCC has been greatly emphasized in recent years. This review summarizes the association between these variables and the potenti