节肢动物蝼蛄和独角仙抗菌活性成分的分离及结构鉴定.pdfVIP

摘要 大肠杆菌有较弱的抑菌活性。 本论文还就天然产物分子卡拉花醛的中间体的合成进行了探讨。通过 2- 甲 基丙二酸二乙酯的烷基化反应，合成了 2- 甲基-2-仲丁基丙二酸二乙酯中间产物 并对该工艺进行了优化。该工作为天然产物化学的修饰改造作了有益的探索。 关 键 词：节肢动物，蝼蛄，独角仙，次生代谢物，分离纯化，结构鉴定，抗 菌活性 论文类型：基础研究 选题来源：国家自然科学基金（No.） II 万方数据 ABSTRACT Secondary metabolites of arthropod insects are the organic compounds of the non-essential small molecules to maintain their celluar activities or normal growing development. The resources of arthropod insects are abundant, which has a long history as traditional Chinese medicine in our country. However, the study of their chemical biological information is far less than those of the plant and marine organism both in China and abroad . To further mine the value of medicial insects, it is thus significance to investigate the arthropod insects including both of their chemistry of secondary metabolites and biological activity. Targeted on Gryllotalpa orientalis Burmeister and Allomyrina dichotoma Linnaeus, the characteristic extracts were obtained using the method of two-stage extraction biocompatibility previously developed in our group. Combined the bioactivity-duided fractionation and the chromatographic separation, the antibacterial secondary metabolites of arthropods were isolated and purfied. The actively lead compounds were then confirmed in in vitro antibactiral tests. The study also investigated into the structural modification and synthesis of natural active compounds,