药剂学英文文献Improvement in solubility of poor watersoluble drugs by solid dispersion(xuebalib.com).pdfVIP

Review Article Improvement in solubility of poor water-soluble drugs by solid dispersion Swati Sareen, George Mathew, Lincy Joseph Department of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India Abstract This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect for various new chemical entities as 60% of the new potential products possess solubility problems. This is the biggest reason for new drug molecules not reaching to the market or not reaches to full potential. There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs. Key words: Dissolution, electrospinning, eutectic mixture, hydrophobic drugs, lyophilization INTRODUCTION Various techniques for enhancement of solubility of poor water-soluble drug Solid dispersion (SD) has been widely used to improve A number of methodologies can be adapted to improve solubilization the dissolution rate, solubility, and oral absorption of poor of poor water-soluble drugs and further to improve its bioavailability. water-soluble drugs. SD refers to the group of solid products consisting of at least two different components, generally a Particle size reduction hydrophilic matrix and a hydrophobic drug; the matrix can The solubility of a drug