复治肺结核合并糖尿病患者抗结核药物耐药分析.docVIP

基金项目：山东省医药卫生科技发展计划（2013WS0146） 作者简介：高绪胜 （1969—），男，副主任医师，研究方向：肺结核合并糖尿病 通讯作者：丁彩红，E—mail： dingdding_64@163.com 作者单位：1 山东省胸科医院结核内科，济南，250013 复治肺结核合并糖尿病患者抗结核药物耐药分析 高绪胜1 熊瑜1 丁彩红1 【摘要】目的 了解复治肺结核合并糖尿病患者耐药状况，为临床防治提供依据。方法 收集2012 年 3月至 2014 年1月山东省胸科医院收住院复治肺结核患者207例，对其进行抗结核药物耐药检测并分析结果，应用 SPSS 16. 0 进行数据统计，两组差异性比较采用χ2检验，以P ＜ 0. 05 认为有统计学意义。结果 复治肺结核合并糖尿病患者总耐药率66.00%，高于单纯复治肺结核患者耐药率62.42%，两组之间差异无统计学意义（χ2=0.21，P =0.39）；复治肺结核合并糖尿病患者血糖大于14.0mmol/l组耐药率最高为77.78%，血糖小于7.1mmol/l组耐药率最低为50.00%，其中血糖大于14.0mmol/l组耐多药率（77.78%）明显高于7.1-14.0mmol/l组耐多药率（33.33%），差异有统计学意义（χ2=4.03，P =0.04）。结论 复治肺结核合并糖尿病患者总耐药率高于单纯复治肺结核患者耐药率，两组差异无统计学意义。复治肺结核患者空腹血糖越高，总耐药率越高。 【关键词】 复治肺结核；耐药；糖尿病；结核分枝杆菌 中图分类号 R521 文献标识码 B Analysis of pulmonary tuberculosis patients complicated with diabetes replication of anti tuberculosis drug resistance GaoXusheng,XiongYu,DingCaihong,Shandong provincial Chest Hospital,Jinan 250013,China Abstract Objective: Analysis the retreatment of pulmonary tuberculosis patients complicated with diabetes drug resistance, and provide basis for clinical prevention and treatment.Method: we collected the data of 207 retreatment pulmonary tuberculosis patients，it from 2012 March to 2014 January in Hospital Shandong provincial Chest Hospital hospitalized, Detection of resistance to tuberculosis drugs and analysis of drug resistance,Application of SPSS 16 statistical data,Chi square test was adopted for analysis. Result: Retreatment of pulmonary tuberculosis patients complicated with diabetes total drug resistance rate of 66.00%, higher than that of resistant pulmonary tuberculosis patients was 62.42%, there was no significant difference between the two groups（χ2=0.21，P =0.39）; the retreatment of blood glucose in patients with pulmonary tuberculosis complicated with diabetes than those in the 14.0mmol/l group the highest resistant rate was 77.78%, glucose is less than 7.1mmol/l group resistance rate of 50.00%,the blood glucose greater than that of the 14.0mmol/l group of multi drug resistant