【精选】恶性肿瘤的分子靶向治疗学习资料课件.pptVIP

. . . . * [slide 2] BAY 43-9006: A Novel Signal Transduction Inhibitor That Combines Two Anticancer Activities1 BAY 43-9006 is a novel signal transduction inhibitor that in preclinical models prevents tumor growth by combining two anticancer activities: inhibition of tumor cell proliferation and tumor angiogenesis. BAY 43-9006 inhibits tumor cell proliferation by targeting the RAF/MEK/ERK pathway at the level of RAF kinase. BAY 43-9006 also exerts an antiangiogenic effect by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR and their associated signaling cascades. Reference: Wilhelm S, Carter C, Tang LY, et al. BAY 43-9006 exhibits broad spectrum anti-tumor activity and targets Raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Clin Can Res. 2003;9 (suppl). Abstract A78. * . . . * * . * 迄今可供临床使用的TM有100余种 ASCO最近发表肿瘤标志物指南特别标明是血中的肿瘤标志物 * . * p53蛋白抑制ras、c-myc等癌基因的转化作用，调节DNA合成的启始 很多人类的实体癌均有p53基因的突变，约70-80%的大肠癌有p53基因的突变 * . * CRP：C反应蛋白 * . . . . . . * AFP具有运输大分子进入细胞、胚胎发育过程中的基因调控、生长调节等重要的生理及生化功能，介导上皮细胞之间的粘附、相互作用以及识别的功能。 甲胎蛋白(AFP):1963年前苏联Ablelev在肝癌移植小鼠中发现了AFP，次年他的同胞Tatarinov在原发性肝癌患者血中发现AFP升高。 1970年以后晚期hcc * . . . * 见于正常成年个体的肝细胞被破坏后的再生（急、慢性肝炎，重症肝炎恢复期，肝硬化）、 * . . . * - Expression of EGFR has been observed in a variety of human tumors, both in vitro and in vivo.[1-15] The increased level of expression found in many tumor types and its consequences on tumor growth provide the rationale for targeting the EGFR in cancer therapy. - The level of EGFR expression varies widely with tumor type. In certain tumor types, EGFR expression is very common. - Variation in EGFR expression observed within studies of a given tumor type could be due in part to a lack of consistency in detection methods, inherent biological differences between tumors, and/or stage of disease. - High levels of EGFR activity can occur as a result of elevated production of receptor ligands (EGF, TGF-alpha). - EGFR expression has been correlated with i