及神经递质的影响.PDFVIP

中国现代医生 2019年7月第57卷第 19期 窑基础医学 窑 淫羊藿苷脂质体经鼻给药对帕金森病大鼠行为学 及神经递质的影响 程志清1 黄建平2银 朱文宗1 支英豪1 赵应征3 1.浙江省温州市中医院袁浙江温州 325000曰2.浙江省温州市中心医院袁浙江温州 325000曰3.温州医科大学袁浙江温州 325000 [摘要] 目的观察经鼻给予淫羊藿苷脂质体对帕金森病模型大鼠的行为学症状及纹状体相关神经递质含量的影 响遥 方法 按随机原则选 16只大鼠为假手术组渊假手术/in组冤袁另将64只造模成功的PD大鼠分为PD模型组 渊PD/in组冤尧淫羊藿苷脂质体经鼻给药组渊ICA-PGL/in组冤尧淫羊藿苷经鼻给药组渊ICA/in组冤尧淫羊藿苷脂质体静 脉注射给药组渊ICA-PGL/iv组冤袁每组 16只遥 药物持续干预2周后袁通过检测大鼠阿扑吗啡旋转次数尧圆筒实验尧 纹状体区TH表达以及相关神经递质含量的改变来观察淫羊藿苷脂质体结合经鼻给药方式对帕金森病模型大鼠 的疗效遥 结果 淫羊藿苷各治疗组运动功能较PD/in组有不同程度的改善袁纹状体区双侧TH 阳性纤维表达及纹 状体区右侧单胺类神经递质DA尧DOPAC和HVA含量较PD/in组均有不同程度的提高, 其中以ICA-PGL/in组疗 效最为突出渊P0.01冤遥 结论 经鼻给药淫羊藿苷脂质体对帕金森病模型大鼠运动功能及神经递质的修复有不错 的疗效遥 [关键词] 淫羊藿苷脂质体曰帕金森病模型曰经鼻给药曰行为学曰神经递质 [中图分类号] R285.5 [文献标识码] A [文章编号] 1673-9701渊2019冤19-0043-05 Effect of intranasal administration of icariin liposome on behavior and neurotransmitterin ratswithParkinsonsdisease 1 2 1 1 3 CHENG Zhiqing HUANG Jianping ZHU Wenzong ZHI Yinghao ZHAO Yingzheng 1.Wenzhou Chinese Medicine HospitalinZhejiang Province, Wenzhou 325000, China; 2.Wenzhou Central Hospital in Zhejiang Province,Wenzhou 325000, China;3.Wenzhou Medical University,Wenzhou 325000,China [Abstract] Objective To observe the effects of nasal administration of icariin liposome on behavioral symptoms and striatum-associated neurotransmitter levels in Parkinsons disease model rats. Methods Sixteen rats were randomly se鄄 lected as sham operation group(sham operation/in group), and 64 successful modeling PD rats were divided into PD model group(PD/in group) and icariin liposome intranasal administration group(ICA-PGL/in group), icariin intranasal administration group(ICA/in group), and i