CTGF表达在肺癌发生发展中地Meta分析.docxVIP

途径。 方法 通过计算机全面检索PubMed、EMbase、CBM、CNKI全文数据库、 外文医学信息资源检索平台、万方数据库、维普、Google学术搜索中 CTGF与肺癌相关的原始文献、会议论文及毕业论文，根据制定的纳入 与排除标准，筛选文献并提取所需数据，采用Cochrane协作网所提供 的Revman5．0软件进行统计分析和处理。 结果 本文最终纳入6篇病例对照研究，均为中文文献。Meta分析结果 显示：肺癌CTGF的表达明显低于癌旁正常组织，CTGF在肺癌组织的 表达与肺癌分化程度、TNM分期、有无淋巴结转移明显相关，而与其 病理分类、性别之间的差异无统计学意义。 结论 肺癌组织CTGF的表达明显低于癌旁正常组织，且与肺癌病理分 化程度、TNM分期、有无淋巴结转移明显相关，提示CTGF表达阳性 越高，肺癌的发生几率就越低，越不具有侵袭性，肿瘤的预后越好， 因此CTGF检测或可作为肺癌早期诊断的一种新方法，为判断肺癌的 生物学行为及预后提供新手段，为肺癌开辟新的生物学治疗途径。 关键词：CTGF，肺癌，Meta分析 万方数据 CTGF EXPRESSION IN THE OCCURRENCE AND DEVELoPMENT oF THE RELATIONSHIP BETWEEN LUNG CANCER AND META．ANALYSIS ABSTRACT Background In recent years，with the in—depth study of the pathogenesis of lung cancer,as well as the development of biology and genetic testing technology,the Molecular targeted therapy has gradually become part of the clinical treatment of lung cancer．Recently studies have found that the expression of CTGF in lung cancers tissues is lower than that in normal lung tissues．CTGF is closely related to the occurrence and development of lung cancer,and it may well become as a new target for diagnosis and treatment of lung cancer，At present，Studies of expression and significance of CTGF in lung cancer have reported in the literature both in domestic and foreign，but the results are not the same，This article uses Meta—analysis methods to systematic evaluation the correlation between CTGF and the occurrence and development of lung cancer，quantitative analysis the results of previous studies on the development of lung cancer and CTGF expression and investigate the clinical significance of CTGF expression and lung cancer． obIi ecfive To collect domestic and foreign literature of the expression of CTGF in lung cancer and paraneoplastic normal tissue，and through the Meta 4 万方数据 analysis compares the expression of CTGF in lung cancer and paraneoplastic normal tissue and look for the correlation between CTGF expression and pathological classification，degr