p基因在急性白血病的表达和临床意义.pptVIP

p基因在急性白血病的表达和临床意义;;研究背景;研究背景; 研究背景;研究背景-p73的作用机制; 研究背景-相关肿瘤研究;研究目的; 研究方法及实验技术;研究方法及实验技术;研究方法及实验技术;研究方法及实验技术;实验结果及讨论 ;实验结果及讨论 ;实验结果及讨论 ;实验结果及讨论 ;实验结果及讨论 ; 结 论; 结 论;[1]李陕区,崔大祥,刘变英等.结肠癌中P73基因改变的意义[J].第四军医大学学报,2000; 21:314-316. [2] Liu M,Taketani T,Li R ,et al.Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation[J].Leuk Res,2001,25(6):443. [3] Roman Gomez J,Jimenez-Velasco A,Castillejo JA,et al.Promoter hypermethylation of Related genes: a strong independent prognostic factor in acute lymphoblastic leukemia[J]. Blood,2004,104(8):2492-2498. [4] Bell HS,Dufes C,O′Prey J,et al.A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.[J].J Clin Invest,2007,117(4):1008-1018. [5] Chi SG,Chang SG,Lee SJ,et al.Elevated and biallelic expression of p73 is associated with progression of human bladder cancer[J].Cancer Res,1999;59:2791-2793. [6] Mendrysa,S. M.,K. A. O’Leary, M. K. McElwee, et al. Tumor suppression and normal aging in mice with constitutively high p53 activity[J].Genes Dev.2006.20:16-21. [7]何勇,童玲,范士志,等.p73基因与人类肿瘤的研究进展[J].肿瘤防治杂志,2005,12 (7):551-554. ;[8]刘明利,李蓉生,林泰秀,等. 儿童急性淋巴细胞白血病患者p73基因表达的研究[J].中华血液学杂志,2000,23(5):242. [9]殷小成,曹励之. p73基因失活在儿童急性淋巴细胞白血病发病和预后的意义[J].实用癌症杂志,2003,18(3):240-244. [10] Mingli liu.Taketani Loss of p73 gene exp ression in lymphoid leukemia cell lines is associated with hypermethylation[J].Leukemia Research,2000,25(6):441-447. [11]殷小成,曹励之. p73mRNA在急性淋巴细胞白血病细胞中的表达及其临床意义[J].中华儿科杂志,2004,42(7):529. [12] Corn PG,Kuerbiitz SI,Van NoeselMM,et al.Transcriptioral silencing of yhe p73 gene in acute lymphoblastic leukemia and Burkitt’s lymphoma is associated with 5’CpG island methylation[J].Cancer Res,1999,59(14):3352-3356. [13]张之南,主编.血液病诊断及疗效标准[M].第三版 北京:科学出版社,1998,214-218. ;谢谢??位！