双环醇保肝抗炎作用研究进展课件.pptVIP

双环醇保肝抗炎作用研究进展;肝细胞损伤和肝脏炎症坏死;转氨酶的功能及临床意义;肝损伤的基本治疗策略;;临床常用的抗炎保肝药物;-不是肝脏和血清ALT和AST活性的抑制剂 -不是肝脏ALT酶蛋白合成的抑制剂 ;百赛诺不是肝脏和血清ALT和AST活性的抑制剂 大鼠肝脏、血清直接温孵法，发现ALT活性不降低 ;*;肝细胞保护剂对转氨酶的作用（体内）;清除自由基、抗氧化;Fig. 10. Time-course changes in plasma endotoxin level in acute alcohol intoxicated mice. Alcohol (6 g/kg) was administered to mice by gavage. The animals were sacrificed at 1.5, 3, 6, and 12 h after alcohol administration. Data were expressed as means±SD (n=6). ??, P0.01 vs. control group.;抗肝损伤-对肝细胞/线粒体膜形态的保护作用;[1]赵冬梅，刘耕陶.双环醇对对乙酰氨基酚致小鼠肝线粒体损伤的保护作用.中国新药杂志，2002，7（11）：536-540 [2]李烨，李燕，刘耕陶.双环醇对实验性肝纤维化的防护作用及分子机制.中华医学杂志,2004,84(24):2096-2101 [3]李 烨，戴国炜，李 燕，刘耕陶.双环醇对扑热息痛弓l起小鼠肝脏能量代谢和线粒体功能障碍的影响.药学学报.2001，36（10）：723-726;抗肝损伤-对肝脏病理形态的保护作用;Fig. 12. Localization of liver TNF-α and CD14 expression in acute alcohol-intoxicated mice. Bicyclol (200, 300 mg/kg) was given orally to mice (n=5) three times before alcohol treatment. Mice were sacrificed at 12 h after alcohol administration. 1: expression of TNF-α; 2: expression of CD14. a: Control; b: Alcohol;c: Pretreatment with Bicyclol. Arrows: Positive cells. Original magnification×100.;抗肝损伤分子机制-抑制炎症导致的肝细胞凋亡;Wang H, Li Y. Eur J Pharmacol. 2006 ;534(1-3):194-201. ;小结;双环醇的临床使用依据;1.双环醇治疗酒精性肝病;双环醇与多烯磷脂酰胆碱治疗酒精性肝病的疗效比较;双环醇与多烯磷脂酰胆碱治疗酒精性肝病的疗效比较;双环醇与多烯磷脂酰胆碱治疗酒精性肝病的疗效比较;双环醇与多烯磷脂酰胆碱治疗酒精性肝病的疗效比较;研究结果及结论;2.百赛诺治疗非酒精性脂肪肝;10;1.百赛诺显著改善肝功能指标;3.百赛诺明显改善B超积分;百赛诺治疗后脂肪变、炎症、纤维化不同程度减轻;检查项目：ALT、AST、TBiL;结果-百赛诺对肝损害??治疗作用;结果-百赛诺对肝损害的预防作用; 本研究表明口服双环醇片可有效治疗化疗药物性肝 损害，中位治疗12天后肝功能即显著恢复。 化疗同时并用双环醇片，患者肝功能损害的发生率 大为下降，程度也明显减轻，保障了化疗按时足量 进行。;Xie W, Shi G, Zhang H, et al. Hepatology International. 2012, 6(2):441-448????;A randomized, multi-central, controlled study of patients with hepatitis B e antigen-positive chronic hepatitis B treated by adefovir dipivoxil or adefovir dipivoxil plus bicyclol;A randomized, multi-central, controlled study of patients with hepatitis B e antigen-positive chronic hepatitis B treated by adefovir dipivoxil or adefovir dipivoxil p