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PRODUCT MONOGRAPH - HIT
®
ORGARAN
Danaparoid Sodium Injection
750 anti-Xa units/ampoule
(1250 anti-Xa units/mL)
Anticoagulant/Antithrombotic Agent
(Heparinoid)
Merck Canada Inc. DATE OF REVISION
16750 route Transcanadienne April 14, 2011
Kirkland, Quebec H9H 4M7
Control #: 144494
® Registered trademark of N.V. Organon, used under license.
1
PRODUCT MONOGRAPH
NAME OF DRUG
®
ORGARAN
Danaparoid Sodium Injection
750 anti-Xa units/ampoule
(1250 anti-Xa units/mL)
THERAPEUTIC CLASSIFICATION
Anticoagulant/Antithrombotic Agent
(Heparinoid)
ACTIONS AND CLINICAL PHARMACOLOGY
®
ORGARAN (danaparoid sodium) is a mixture of non-heparin low molecular weight sulfated
glycosaminoglycuronans derived from porcine intestinal mucosa. Its average molecular weight is
4000-8000 D and the molecular weights of the fractions range from 2000 to 10000 D.
®
ORGARAN consists of heparan sulfate with low affinity for antithrombin (AT) (about 80%),
heparan sulfate with high affinity for AT (about 4%), dermatan sulfate (8-16%) and chondroitin
®
sulfate (8.5%). ORGARAN is devo
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