二甲双胍可抑制重度CKD及相关矿物质及骨代谢异常的进展.pptVIP

Results-- Effect of metformin on mineral homeostasis (c) serum phosphorus, (d) serum calcium *P 0.05 versus vehicle; ¤ P 0.05 versus week 0 (vehicle group); #P 0.05 versus week 0 (metformin group). Results-- Effect of metformin on renal function and mineral homeostasis (e) serum parathyroid hormone (PTH), and (f) serum FGF-23 in chronic kidney disease (CKD) rats treated with vehicle *P 0.05 versus vehicle; ¤ P 0.05 versus week 0 (vehicle group); #P 0.05 versus week 0 (metformin group). PH (7.40 ± 0.02 in the vehicle group vs. 7.36 ± 0.03 in the metformin group) Bicarbonate (31.75 ± 0.77 mmol/l in the vehicle group vs. 27.78 ± 1.93 mmol/l in the metformin group) Hematocrit (34.08% ± 1.47% in the metformin group versus 26.18% ± 1.73% in the vehicle group; P = 0.001) Serum hemoglobin concentration (11.60 ± 0.50 g/dl in the metformin group vs. 8.89 ± 0.59 g/dl in the vehicle group; P = 0.001) Results--Acid/base balance and anemia Results--Impact of metformin treatment on vascular calcification in adenine-induced CKD rats Total calcium content in the (a) aorta, (b) femoral artery, and (c) carotid artery in vehicle (n = 14) versus metformin-treated rats with chronic kidney disease (n = 13).*P 0.05 versus vehicle. von Kossa-stained sections of (d) a calcified aorta of a vehicle-treated rat and (e) an intact aorta of a metformin-treated rat. Results--Impact of metformin treatment on vascular calcification in adenine-induced CKD rats Results-- Impact of metformin treatment on static and dynamic bone parameters Hatched zones represent mean ± SD data for rats with normal renal function；*P 0.05 versus vehicle 各位老师，师兄师姐，大家晚上好。今天要给大家分享的是一篇18年发表在KI 上的文章。题目是：二甲双胍可抑制重度CKD及其相关矿物质及骨代谢异常的进展。 在过去的几十年里，二甲双胍因其对代谢的影响而被用作2型糖尿病的一线治疗。 对糖代谢的影响，二甲双胍可提高胰岛素敏感性，从而刺激外周葡萄糖摄入，促进糖酵解，抑制肝糖原的异生。 然而，二甲双胍除了的降糖的作用，对肾脏的作用也日益显现。因为二甲双胍经肾脏排泄，考虑到有乳酸性酸中毒的可能，对晚期肾脏疾病患者来说，是禁用二甲双胍。也因此原因，目前二甲双胍对肾脏影响的研究很少，且都仅限于基础研究。 既往研究显示，在庆大霉素诱导的肾病大鼠模型中，二甲双胍的治疗完全阻断了急性肾功能衰竭的发生，阻止了肾脏组织学的改变，使氧化应激正常化。此外，研究还表明，二甲双胍还能够改善5/6肾切