湘雅医学院文献阅读技巧选修课展示课件 Cirrhosis.ppt

Cirrhosis Key words： 1.cirrhosis 2.macronodular cirrhosis 3.micronodular cirrhosis 4.mixed micro\ macronodular cirrhosis 5. consumption of alcohol 6.hepatitis viruses 7.portal hypertension 8.hepatocellular failure 1. The ancient Greeks recognized the clinical features of cirrhosis. 2. In the seventeenth century , sporadic reports of the cirrhotic liver appeared. 3. Matthew Baillies accurate description in 1793 established cirrhosis as a nosological entity in pathology. 4. During the mid-nineteenth and late-nineteenth century , technical innovation has advanced our understanding of cirrhosis. History Definition Cirrhosis is a chronic hepatic disorder, anatomically characterized by diffuse liver fibrosis and nodule formation. Classification Classification Cirrhosis is classified on the basis of morphology and etiology. The international classification recognizes three types based on the size of the nodules .However ,Chinese classification are based on pathogenesis and clinical manifestations. Classification The international classification Cirrhosis Macronodular cirrhosis Micronodular cirrhosis Mixed micro\ macronodular cirrhosis Classification Chinese classification Cirrhosis Portal cirrhosis Biliary cirrhosis Postnecrotic cirrhosis The worldwide incidence of cirrhosis is determined chiefly by the per-capita consumption of alcohol and the prevalence of the hepatitis viruses. mainly hepatitis(A, B virus) 20-60% of chronic disease 1.chronic right heart failure 2. Budd-Chiari Syndrome 3. Veno-occlusive disease Common Etiology Toxins and drugs Hepatitis virus Vascular disease alcohol, methyldopa and isoniazid 5-15% of chronic alcoholic The factors that would modify occurrence of cirrhosis： 1. Geography, race, age, sex, economic, social class and occupation; 2. The amount, duration ,and pattern of alcohol consumption; 3. Prevalence of hepatitis viruses.