附录2-技术和方法课件.ppt

Biochip technique Gene chip: consists of an arrayed series of thousands of microscopic spots of DNA oligonucleotides, called features, each containing picomoles (10?12 moles) of a specific DNA sequence, known as probes. Protein chip: provides a multiplex approach to identify protein–protein interactions, to identify the substrates of protein kinases, to identify transcription factor protein-activation. Tissue array: consist of paraffin blocks, separate tissue cores are assembled in array fashion to allow multiplex histological analysis. \ Molecular imaging Application of imaging methods, on